The BK Channel Opener Phloretin Influences Voltage- and Calcium-Dependent Gating
نویسندگان
چکیده
منابع مشابه
State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels.
Large-conductance voltage- and calcium-dependent potassium channels (BK, "Big K+") are important controllers of cell excitability. In the BK channel, a large C-terminal intracellular region containing a "gating-ring" structure has been proposed to transduce Ca(2+) binding into channel opening. Using patch-clamp fluorometry, we have investigated the calcium and voltage dependence of conformation...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.3716